Depression Raises Risk of Early Death


A large, long-term study has confirmed that both men and women who have had at least one major depressive episode have a significantly higher mortality risk. Moreover, this risk has progressively increased for women.

Depression is one of the most widespread mental disorders among adults in the United States. According to data provided by the National Institute of Mental Health, 6.7 percent of all U.S. adults had at least one major depressive episode in 2015 alone. A major depressive episode, as defined by the Diagnostic and Statistical Manual of Mental Disorders, occurs when five or more of the following symptoms are consistently present for a period of 2 weeks: depressed mood, loss of pleasure in normally pleasurable activities, abnormal weight loss or weight gain, sleeplessness or oversleeping, abnormal physical agitation or slowness, fatigue, feelings of guilt or worthlessness, lack of focus, and “recurrent thoughts of death.”

Photo credit : Shan Tell’em

Existing research has already linked depression to a heightened risk of cardiovascular disease and sudden cardiac death, especially in women.

And now, a study recently published in the Canadian Medical Association Journal points to major depressive episodes as a significant risk factor of early death for both men and women.

The study was conducted by researchers from across U.S. and Canadian institutions, including the Eunice Kennedy Shriver National Institute of Child Health and Human Development (of the National Institutes of Health) in Bethesda, MD, and the School of Epidemiology at the University of Ottawa in Ontario, Canada.

“There is less stigma associated with depression, better treatments are available, but depression’s link to mortality still persists. At first, the association was limited to men, but in later years it was seen for women as well.”

Depression tied to ‘elevated risk of mortality’

The team analyzed data sourced from 3,410 adults from Atlantic Canada enrolled in the Stirling County Study, which focused on gaining a better understanding of various mental illnesses.

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In the current research, the authors were interested in seeing to what extent depression was linked to a heightened mortality risk, and whether this risk was different for men versus women.

They conducted their study over 60 years, analyzing data from participants enrolled during three distinct periods: 1952–1967 (1,003 participants), 1968–1990 (1,203 participants), and 1991–2011 (1,402 participants). The participants’ mean age at the time of enrollment was 49 years.

This information was also linked to death records from the Canadian Mortality Database.

A strong connection between a diagnosis of depression and a significantly increased risk of mortality was noted for men across all three periods. For women, however, a link between depression and risk of death was only observed from the 1990s onwards.

Moreover, the team reports that the most severe risk of death follows a depressive episode, but also that this risk might be counteracted by an improvement in the individual’s mental health.

Medical News Today