What do you Understand by Mechanism of Valproate Action?

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a) Facilitation glutamic acid decarboxylase, the enzyme responsible for GABA synthesis and inhibition of GABAaminotransferase, the enzyme responsible for the breakdown of GABA (enhance GABA accumulation)

b) Inhibition of voltage sensitive Na+ channels

c) Inhibition of low threshold (T-type) Ca2+ channels

d) All of the above

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