What do you know about Phenytoin

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Plasma concentration of phenytoin is increased by:
1 amoxicillin
2 doxycycline
3 clarithromycin

ONE or MORE of the responses above is (are) correct. Decide which of the responses is (are) correct. Then choose:
A if 1, 2 and 3 are correct
B if 1 and 2 only are correct
C if 2 and 3 only are correct
D if 1 only is correct
E if 3 only is correct

11 COMMENTS

  1. The answer is E, winners are O’can and Odogwu. Details below:
    Metabolism of phenytoin (anti-epileptic drug) is inhibited by clarithromycin
    (macrolide antibacterial agent) resulting in an increased plasma concentration
    of phenytoin. Phenytoin accelerates metabolism of doxycycline (tetracycline
    antibacterial drug) resulting in a reduced plasma concentration of doxycycline.

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