Isosorbide dinitrate?

5
381

1 is used for prophylaxis of angina
2 is metabolised to isosorbide mononitrate
3 can only be administered sublingually

A 1, 2, 3
B 1, 2 only
C 2, 3 only
D 1 only
E 3 only

5 COMMENTS

  1. B is the answer and there is no winner for this question.
    Details Below:
    Isosorbide dinitrate is a nitrate that is used in the prophylaxis and treatment
    of angina and in left ventricular failure. In AB isosorbide dinitrate is being
    used for the management of heart failure. Nitrates cause vasodilatation and
    lead to a decrease in preload. Isosorbide dinitrate is metabolised to active
    metabolites, the most important of which is isosorbide mononitrate. It is
    available as short-acting tablets which may also be used sublingually in
    angina, as an aerosol spray, as modified-release oral dosage forms and as
    injection for intravenous infusion. The dose for isosorbide dinitrate in heart
    failure is 30–160 mg in divided doses but the dose may be increased to
    240 mg daily.

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