What do you Understand by local anesthetics?

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Which one of the following statements about the metabolism of local anesthetics is incorrect?

a) Metabolism of local anesthetics occurs at the site of administration

b) Metabolism occurs in the plasma or liver but not at the site of administration

c) Ester group of anesthetics like procaine, are metabolized systemically by pseudocholinesterase

d) Amides such as lidocaine, are metabolized in the liver by microsomal mixed function oxidases

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